USING INTEGRATED BIOINFORMATICS ANALYSIS TO IDENTIFY ABNORMALLY METHYLATED DIFFERENTIALLY EXPRESSED GENES IN HEPATOCELLULAR CARCINOMA

Qing-Lian Chen,1,2,* Qian Yan,1,* Kun-Liang Feng,1,2,* Chun-Feng Xie,1,2,* Chong-Kai Fang,1,2 Ji-Nan Wang,1,2 Li-Hua Liu,2,3 Ya Li,3 Chong Zhong2,3 1Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China; 2Department of Hepatobiliary Default Surgery, The First Affiliated Hospital of Guangzhou University of Chi

Checkpoints are surveillance mechanisms that constitute a barrier to oncogenesis by preserving genome integrity.Loss of checkpoint function is an early event in tumorigenesis.Polo kinases (Plks) are fundamental regulators of cell cycle progression in all eukaryotes and are frequently overexpressed in tumors.Through their polo box domain, Plks targe